As aspiring bomb disposal experts, the players in Bomb Busters must work together to defuse a bomb before it explodes! To complete their mission successfully, they must cut pairs of identical wires: one half which is always in their own hand and the other half to be found among the hidden wires of one of their teammates. Each numbered wire from 1 to 12 is found in the game exactly four times and each team member's wires must be organized in ascending order. Both facts are important as players deduce how to cut two wires with the same number, every success bringing them one step closer to defusing the bomb. However, each time they cut wires with different values, players risk an explosion. If players ever cut a red wire, there is an immediate explosion and the game ends. Yellow cables with decimal numbers bring additional challenges to the game and equipment cards help with particularly tricky missions.

Bomb Busters is a cooperative deduction game with 66 increasingly dangerous missions and includes five surprise boxes with additional rules and materials. The wires are only ever cut in the metaphorical sense, game components are not destroyed during play.