In Corps of Discovery: A Game Set in the World of Manifest Destiny, Lewis and Clark are tasked with exploring America while also ridding the land of numerous invasive monsters that have appeared.

Each player takes the role of one of the crew members on the expedition as you set out to explore the land together. The game board allows different maps to be inserted, giving you many adventures to explore.

In addition to finding and killing monsters, you must complete numerous daily challenges that require specific resources found on the board. You will need to use logic and deduction to work out where the resources you need are located. Ally yourselves with Sacajawea and the indigenous people of the area to help you on your quest.

The game comes with two chapters: Fauna and Flora. Each chapter introduces new mechanisms, a different goal, and new components to give it a distinct feel.