In Entropy, players take on the role of scientists who move their Scientist piece 1 to 3 spaces clockwise around the main board each turn, over a variable number of rounds. Every move must end on either an inner action space on the main board or an outer space on one of the action tiles, triggering the corresponding action.

Throughout the game, players build their own Solar Systems by adding Stars, Planets, and Asteroids, then populate them with Life by playing cards. Special abilities can also be unlocked by adding Biomes and upgrading the player's Console.

The game ends once any 2 of the 6 Main Objectives have been completed. When the game ends, the player with the most Victory Points wins.

Entropy delivers a demanding economic strategy experience built around rondel movement, card collection, and building your own corner of the universe, appealing especially to fans of thoughtful sci-fi games.